Dynamics of HIV-1 mRNA expression in patients with long-term nonprogressive HIV-1 infection.
نویسندگان
چکیده
منابع مشابه
Dynamics of HIV-1 mRNA expression in patients with long-term nonprogressive HIV-1 infection.
A large number of evidences indicate that progression of HIV disease is driven by an increase in viral burden. It is still unclear, however, to what extent this is contributed by the dysregulation of the molecular mechanisms governing virus gene expression at the transcriptional or posttranscriptional levels. To address this issue, several quantitative virologic parameters (including provirus t...
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levels fall to lower steady-state values that vary in differA great deal of progress has been made in understandent individuals and that are predictive of the rate of ing the molecular biology of HIV-1 replication (see redisease progression (Mellors et al., 1996). In untreated views by Cullen [1998], Chan and Kim [1998], and Littasymptomatic patients, the plasma HIV-1 RNA levels man [1998] in t...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119605